Excipients, drug release mechanism and physicochemical characterization methods of Solid lipid nanoparticles

From last thirty years, solid lipid nanoparticles (SLNs) gain much importance as drug delivery vehicle for enhanced of the drugs, proteins, nutraceuticals and cosmetics. SLNs defined a submicron size range nanoparticle with below 1000 nm are mainly composed lipids surfactants, capable incorporating both lipophilic hydrophilic drugs. also used controlled systems, targeted altered therapeutic efficacy purpose. A wide variety methods such double emulsion, solvent evaporation, ultra sonication, high-pressure homogenization microemulsion production. This review provides significance in highlighting on selection excipients, release mechanism, principles limitations associated their physicochemical surface morphological characterization.
 Keywords: Solid nanoparticles, delivery, preparation, characterization, application.